Citizens Identities in Public Documents

Contained herein is an article critique regarding exposure of private information through digitization projects that allow unrestricted public access.The analysis will specifically deal with John Harney’s Protecting Citizens Identities in Public Documents that highlights how a County document preservation department dealt with the issue of protecting public information effectively.In the understanding that exposing private data such as social security, bank account numbers and title deed, the Maricoba County Recorder embarked on an elaborative process of scanning and removing all the sensitive information from documents without diluting usefulness.The County’s efforts are important considering the dangers of exposing such data to other people. Indeed, the exposure would make it easy for phishers to collect information that is later used for identity theft. Harney’s article is therefore an important eye-opener that it is possible for society to utilize new technol ogies effectively without posing dangers to individuals’ private lives. Maricoba County’s processes should therefore be regarded as best practices in digitization field.This is especially because members of the public would be more supportive of such projects and therefore be more willing to volunteer donations and propositions. Such collaboration would help in the process of digitizing the millions, maybe billions, of documents and information whose digitization would improve public awareness on past and current issues affective respective society.In addition, the end of public’s phobia of digitization and privacy will indeed be help in motivating technology makers in improving ways of improving security features further. John Harney’s Protecting Citizens Identities in Public Documents is in this regard an important contribution to the debate of digitization and information security.ReferencesHarney, J. (2008). Protecting Citizens Identities in Public Do cuments. Retrieved March    3, 2009, from http://www.infonomics-digital.com/infonomics/20080304/?pg=60

Healthy Eating Pyramid Essay

The â€Å"Healthy Eating Pyramid† is a guide to eating a healthy diet. What is a healthy diet for you depends not only on your age and sex, but also on your body condition. This article gives an insight into the Healthy Eating Pyramid. Read on†¦ Many people have a wrong notion about the concept of healthy eating. Youngsters think remaining thin by depriving themselves of all foods they love to eat is healthy eating. However, they are wrong. Healthy diet has nothing to do with remaining thin by depriving oneself of food. A healthy and nutritious diet should impart a sense of well-being and make you feel energetic. The Healthy Eating Pyramid – Tips Harvard School of Public Health developed a nutrition guide for healthy eating called â€Å"The Healthy Eating Pyramid†. The principles underlying the Healthy Eating Pyramid stress mainly two things. They are regular exercise and weight control. The Healthy Eating Pyramid lays the foundation of healthy eating in eating more of vegetables and whole grains and less of red meat and refined grains. Here are a few tips to follow â€Å"Healthy Eating Pyramid†. Regular Exercise – Regular exercise is the basic principle for any healthy diet pyramid. The reason is it helps to keep your weight in check. Focus on Food You Eat – The Healthy Eating Pyramid guides you to what kind of food you should eat, how you should eat and when you should eat. It advises you as to the number of servings you can eat. So eat your fill of healthy food and do not worry about the calories. Give Importance to Vegetables – This guide stresses on a vegetarian diet that includes plenty of fruits and green vegetables daily. You can also use whole grains and healthy fats such as canola and olive oil. Avoid Red Meat – The healthy nutritional guide advises on avoiding red meat such as beef and mutton. It would be a good idea to forgo refined grains, carbonated/sugary drinks, potatoes and salty snacks. Instead of red meat have fish or lean meat such as turkey, chicken and other poultry. Have a Multivitamin Daily – This healthy diet pyramid suggests the inclusion of multivitamins in your daily diet. The Healthy Eating Pyramid – Different Levels There are six levels in the â€Å"Healthy Eating Pyramid† and each level has a group of foods recommended in your daily diet. First Group – The food belonging to this group includes breads and cereals. You can have maximum 10 to 12 helpings a day. Grains form the basis of this level. Second and Third Groups – The food items falling in this group include vegetables and fruits. They are a source of fiber and vitamins. The health pyramid recommends at least 4 servings a day. Fourth Group – The fourth food level consists of dairy products like cheese, milk, and yogurt. The â€Å"Healthy Eating Pyramid† recommends 3 servings per day. Fifth Group – Foods that provide vitamins, minerals and protein are included in this group. Some of the foods recommended in the fifth level are meat, poultry, eggs and fish. You should also include dry fruits, nuts and beans. Have at least 2 helpings a day. Sixth Group – This is the last group in the â€Å"Healthy Eating Pyramid† and is placed at top in the food pyramid. These food items are high in sugar and fat. It is wise to consume these foods sparingly. A significant feature of this healthy pyramid is it gives importance to the quality and not the quantity of food you eat. A recent update to the â€Å"Healthy Eating Pyramid†, is the inclusion of salt to the sixth group, and recommends adding salt sparingly to your food. It also suggests including Vitamin D daily in your diet.

A Worn Path Essays - Eudora Welty, Term Papers

A Worn Path In the story "A Worn Path" the main character's name is Phoenix which alludes to "the mythical bird that consumed itself in fire after five hundred years and rose renewed from its ashes. This death-birth motif gives a meaningful context for details which seem merely descriptive"(Seidl, p. 53). "Welty's main subject is the intricacies of human relationships, particularly as revealed through her characters' interactions in intimate social encounters. Welty's outlook is hopeful, and love is viewed as a redeeming presence in the midst of isolation and indifference" (One Writers Beginnings). Ms. Welty takes an old woman, Phoenix Jackson, on a seemingly impossible journey using general symbolism and Christian symbolism. She begins the journey with general symbols of everyday life. The journey itself is like life, it has its ups and downs. "The woods were deep and still" (Welty, p. 159) and "Down in the hollow was the mourning dove" (Welty, p. 159) makes the reader think of death. Other symbols that make us think of life or youth and death or age are: "Seem like there is chains about my feet" (Welty, p. 159) make it clear that Phoenix is thinking about death or slavery; "Up through the pines" (Welty, p. 159) makes the reader think of youth; "Now down through the oaks" (Welty, p. 159) is another symbol of death; "She had to creep and crawl, spreading her knees and stretching her fingers like a baby trying to climb the steps" (Welty, p. 160)is another sign of youth; Phoenix's hair and eyes also make us think of youth and death since the reader knows S. Carney 2 Phoenix is old because of the repeated use of "old," and "Granny," and "Grandma" but her hair is not gray but "still black" (Welty, p. 159); Phoenix also saw a buzzard in the field, making Phoenix think of death; "I walking in their sleep" (Welty, p. 160) is a phrase used by Phoenix as she walked "past cabins silver from weather, with the doors and windows boarded shut"(Welty, p. 160) that makes the reader think Phoenix has outlived just about everyone she has known in her life. Other symbols of death are where "the live-oaks met" ... "it was dark as a cave"(Welty, p. 161); The "black dog" (Welty, p. 161) who knocked Phoenix in the ditch; the scarecrow is a reference to death in the story because Phoenix performs a little dance of death with it; and finally how Phoenix slowly bends forward, her chin almost even with her knees as she picked the nickel up off the ground. Some of the Christmas symbols certainly portray Christian symbolism. As Phoenix crosses a log that "was laid across the creek" the reader thinks of crossing the river Jordan; Phoenix "carried a thin, small cane made from an umbrella" (Welty, p. 158) makes the reader think of a candy cane; "a tree in a pearly cloud of mistletoe" (Welty, p. 159) is also another sign of Christmas; the "red and green electric lights" (Welty, p. 162); the bells ringing also remind Phoenix that it is Christmas time in the city; the lady that "came along in the crowd, carrying an armful of red-, green-, and silver-wrapped presents" (Welty, p. 163) who tied Phoenix's shoe and the attendant who gives her a nickel make the reader think of Christmas as a time for giving; as the reader S. Carney 3 thinks of Phoenix's grandson we also think of Jesus; and finally as Phoenix is going to the store to buy her "child a little windmill" makes us think of the star. "A Worn Path" suggests that "the end of the road is death and renewal of life" (Seidl, p. 54). By looking through the eyes of Phoenix the reader learns that life is a path filled with mental deaths and rebirths. Everyone is frequently close to giving up against everyday struggles; yet through equivalently frequent aids, you persist on spiritually revived. If you have a good enough cause you do not give up. S. Carney 4 Welty, Eudora, One Writers Beginnings, Internet, 1994 Seidl, Frances. Eudora Welty's Phoenix. Vol. 6 of Notes on Mississippi Writers, University of Southern Mississippi, 1974. Welty, Eudora. "A Worn Path." Literature for Composition. Ed. Sylvan Barnet,

Working in the community (fire figthers.) Essay

Working in the community (fire figthers.) - Essay Example http://www.cdc.gov). Prevention labor is part of fire fighters' educational programs, which are addressed both to children and adults in order to avoid, as far as possible, injures and deaths produced by the fire. This labor is developed with their community and national programs. "NFPA (National Fire Protection Association) teaches people of all ages how to make responsible choices regarding health and safety. One of our most important commitments is to give people the knowledge and skills they need to lead safer lives" ("Education Programs", National Fire Protection Association. http://www.nfpa.org). Children are one of these groups and fire fighters usually talk to them about the risks of a variety of things that may cause fire or other accidents. These programs usually include very easy tips about security in the house: things that are potentially dangerous, things that may cause a fire, things to be careful with or to use under the supervision of an adult. These days, internet is increasingly becoming an important teaching method, so most of Fire Departments include a specific section for children on their websites. This is a complement for the labor they carry out in schools, where they talk to children about fire risks, teach them how to prevent and how to act when a fire starts and carry out fire drills. Usually, the person who talks in schools is a member of the community which takes part in some volunteer program. On the websites, most of the fire prevention tips are usually presented as attractive interactive games for children, with eye-catching animations, like the program of the National Fire Protection Association. In their "Risk Watch Safe Community Program" we can find complete information on how to teach children to prevent unintentional injuries or injuries that can result from natural disasters ("Risk Watch Safe Community Program", National Fire Protection Association. http: //www.nfpa.org.). They use games that attract children's attention, like searching the hazardous elements in the picture of a room, making them aware of the elements they need to play safe or helping Sparky the Fire Dog to complete his emergency kit. Sparky, which is dressed as a fire fighter, has his own website (http://www.sparky.org) in which children can learn more about the labor of fire fighters: the different types of trucks, why Dalmatians are the "official" dogs of fire departments and they can also ask him questions about his duty. The United States Fire Administration is another good example of these interactive games for children. On their website, they will find plenty of educational activities like puzzles, coloring pages, matching games and even a quiz to become a Junior Fire Marshal. Also the Chicago Fire Department has its Kids' Section, with entertaining coloring books for little children. The school programs are a very interesting way to warn and prevent children from fire risks. They will see fire prevention as a part of their education. As fires can start whether at home or at school,

Is it Correct for Successive Governments to Manipulate the Personal Research Paper

Is it Correct for Successive Governments to Manipulate the Personal Taxation System for Economic Purposes - Research Paper Example Individual income taxes often tax the total income of the individual (with some deductions permitted), while corporate income taxes often tax net income (the difference between gross receipts, expenses, and additional write-offs)† (Balachandran 2010, p. 146). Taxation in the UK may involve payments of two different layers of government, the National Government and the Regional Government. The central government taxes include revenues and Customs. The central Government revenue comes primarily from Income Tax, National Insurance, Contribution of VAT, Corporate Taxes and Fuel Duty. The income tax forms the single largest source of revenue collected by the government. In the UK, each person has a taxable income and personal allowance up to a certain amount, free for everyone. The success of the personal taxation system depends upon the principles of taxation procedure. Taxable income is in different ways - depends on income and employment status. â€Å"These include PAYE (Pay As You Earn), self-assessment, tax deducted at source, and one-off payments† (Ways You Pay Income Tax n.d.). There are four important canons of taxation. They are economic principles, it includes the cost-effectiveness and how should cost less to collect the taxes than the revenues. A system of tax in the UK is reflected the communal values and power. To create a taxation system, a nation makes the choice of distribution for the tax that will pay the taxes and how much amount will pay for the tax. And the government can decide how will spent the collected taxes. The government collects taxes in a cost-effective manner.  

System Analysis and Design course Essay Example | Topics and Well Written Essays - 1250 words

System Analysis and Design course - Essay Example The scope of the project is to give a plan which illustrates to draw an amount of $800 from the monthly earning or we can say from disposable income by managing the routine expenses within the same income. The expected length of the saving plan would be 5 months i.e. starting from 1st of March 2014 to 1st of July 2014. I hope that during the period of 5 months I will be able to accumulate the amount of $800 in order to purchase the iPad. In order to be successful in my saving plan, there must be a saving of $160-180 per month. In case of any decrease in the saving amount per month I may not be able to purchase the desired model of iPad in the expected time period. One more important thing, I may reduce my frequent visits to nearby fast food restaurants along with my friends. This will definitely cut down my extra expenses. The basic purpose or the objective of this study or report is to devise an information system which helps to manage the time spent in different activities of daily routine life. Time management is very much necessary in the life because now the philosophers consider time value as an asset which should be properly utilized so that an individual can take full advantage of it. The scope of the essay is to devise a time management plan for best use of time. This will look at the past behavior of how time has been used how the time was saved during the college period. This time management will help to maintain the resources in later years. We have to give a proper time to our college activities because these cannot be compromised at all or we can say at any cost. Though the college schedule is set keeping in mind the personal activities also but the time plan should give ample time to the study duration. If I look back to my past activities then I might come to know that at certain times I failed to properly allocate time. This failure caused certain problems for me. Now I

Moral Dilemmas Essay Example | Topics and Well Written Essays - 500 words - 2

Moral Dilemmas - Essay Example In stating about this problem, Russ Shafer-Landau argues that various moral principles tend to be effectively independently to how an individual perceives them. Kant’s moral theory is slightly different especially how people perceive it. In defining moral dilemmas, the Kant moral theory is seen as deontological whereby a person’s actions are morally upright in terms of virtues of individual’s motives. In this case, they must derive from a certain duty than inclination (Timmons 27). The determination to act according to his/her duty mostly overcomes the self-interest evidence or the desire to do otherwise. Moreover, Kant argues the aspect of moral values of an individual’s actions with the fact that they only reside in maxim or formal principle. Alternatively, it explains about the general commitment of a person to engage in a certain act because it is his/her duty to do so (Timmons 35). This therefore means that, duty remains the necessity for a person to act out of vengeance for the law. Rigorous application of similar methods towards this reasoning would result in an equal success while dealing with moral philo sophy problems. This therefore means that the eventual principle of morality must always be a moral law that happens abstractly and has the ability of guiding an individual towards a right action. In as much as the Kant’s theory seems effective and applies to real life events, this theory of ethics has its own flaws and ineffectiveness when used literary (Timmons 32). Generally, the theory fails to tell people what they should do especially when their moral responsibilities are conflicting. Kant’s theory of ethics is entirely general especially on some of the common happening in terms of moral ethics and dilemmas. However, the theory is not detailed and effective enough to guide people on how to

Leadership and Organisational Behaviour Case Study

Leadership and Organisational Behaviour - Case Study Example W.L. Gore & Associates is also known for its ability to develop innovative fabrics and polymer products which can be used for industrial, leisure, electronic and medical purposes (Gore, 2013). The case study will be analyzed on the basis of various theoretical frameworks regarding leadership and organizational behaviour and the researcher will use conjectural view in order to address pertaining issues in the case study. The researcher will mainly use four types of aspects such as leadership theories, team leadership, organizational behaviour and group dynamics in order to analyze the cases study. The researcher will take help of the theoretical argument of various research scholars in order to substantiate the proposed theoretical framework for the cases study and there will be separate literature review in the paper which will present theoretical arguments of various research scholars. In the next part of the paper, pertinent aspects of the case study will be analyzed in the light o f theoretical framework. In the last section, the researcher will recommend some suitable strategies which can help W.L. Gore & Associates to address any future problems in sustainable manner. Paradigms of the Case Study Careful analysis of the case study reveals the fact that the case of W.L. Gore & Associates is exceptional when it comes to comparing work culture in other organizations. The case study was written by considering leadership and organizational behaviour theories such as, 1- mutual trust development in a team, 2- leadership, 3- shared value within the team members, 4- managing a knowledge sharing and organic culture and 5- zest for constant innovation. Now, the question is whether the case study has been succeeded to address all the above mentioned theoretical aspects? Giving answer to the question is not a simple task and neither the researcher is in a position to judge the merit of the case study. However, the case study should be appreciated for its effort to unloc k the success mystery for W.L. Gore & Associates by integrating some of the prominent leadership and organizational behaviour theories. The researcher has found that above mentioned five aspects of the case study needs theoretical consideration in order to analyze the case study in terms of some well established leadership and organizational theories. Hence, the researcher has decided to conduct a literature review in order to explain pertinent aspects of the case study in the light of theoretical judgement of eminent research scholars. Literature Review It is evident from the case study that W.L. Gore & Associates has carefully replaced the concept of managing from external periphery with the concept of self managed individuals who can achieve leadership position by disposing skill and knowledge. Orsburn and Moran (2000) argued that self managed work groups are far more flexible in comparison to bureaucratic structure. Pearce and Manz (2005) pointed out that modern organizations ha ve trying to experiment with the organizational dynamics and organizational culture which can improve their productivity. Pearce and Manz (2005) defined self managed leaders are those who do not need external pressure to achieve the performance objective in workplace rather they

Childcare studies (Working with Children) Assignment

Childcare studies (Working with Children) - Assignment Example The international desire to improve the quality of childcare and pre-school provisions has contributed a great deal in ensuring that children receive high quality education and childcare as they start their journey of life in educational set-ups (Shaw & Brewer 2012, pg 60). This paper will delve into details of the several provisions needed for childcare, the various types of environments and establishments relating to child development, the skills required as well as the training needed for the numerous childcare roles and working environments. There are various types of childcare and educational provisions. These provisions fall under both formal and informal sectors. These provisions include nursery education, playgroups, child-minders, crà ¨ches, pre-school, care homes, just to mention but a few. Nursery education is aimed at giving additional physical, social, emotional and cognitive support to children when they are outside the home. Nurseries are normally attended by children aged between two and five. These facilities are normally offered free of charge by Local Education Authorities (Dates 2004, pg. 54). However, if offered by private institutions or organizations then are subject to fees. Nursery schools are normally staffed by teachers who are trained. They are normally assisted by nursery nurses as well as other support staff comprising of volunteers, nursery and teaching assistants (Dallimore 2004, pg. 98). Pre-school is another provision offered to children. These facilities are usually attached to primary schools and are meant for children of ages four. Pre-schools are normally staffed by highly trained teachers and support staff. They are charged with the responsibility of preparing children for school (Laming 2003, pg. 43). It is important for children to attend pre-school before joining primary school since it gives them an insight of what to

I dont belive in ghost Essay Example for Free

I dont belive in ghost Essay I dont belive in ghost!,I said to my grand mom.But she shocked me by saying her horror incident that she experienced .A fort night ago,she was alone at home and we children were playing in the garden.She was going to watch a horror movie.A very thrilling scene was going to happen,she said.Suddenly the lights started to flicker and there was a powercut. She heard nises f someone counting numbers.As it counted till ten,it saidI am coming. She got scared.She went to switch on the emergency light but unfortunately it was not charged. It was really dark. Some how she managed toreach her room. She sat on the bed and started to pray. She heard noises,but as she was scared she did not go to see who was there. She heard noises of doors shutting,someone saying shhhhhhhh,and so on. As soon as the light came, she came outand saw that there was no one.After narrating the whole story she said that she believed in ghost. I suddenly started to lauh and said that it does not make sense.Evil spirits and ghost donot exist. I told her actually what happened. We cousins were playing in the garden.As it started btto rain,thre was a sudden powercut. We came in and then decided to play hie and seek. One of us started to count and we all started to hide ourselves.I said t her that we were the ones who made that noises.As the rain stopped,the light came an we went back to the garden for playing.Thats the reason she could notsee anyone in the house.I tld her not to believe in such incidents and try to find the logic behind it. She lso started to laugh. i would like to convey a massage that never ever believe in ghost.

Exogenous IL-10 and Golimumab for Heart Failure Treatment

Exogenous IL-10 and Golimumab for Heart Failure Treatment Synergistic Effect of Exogenous IL-10 and Golimumab in the Treatment for Heart Failure in Rats Running title: Heart Failure Treatment Highlights: The level of TNF-ÃŽ ± decreased after treatment with IL-10 and golimumab. The level of IL-10 was increased by IL-10 combined with golimumab. IL-10 and golimumab have a synergistic effect on HF in rats. ABSTRACT Objectives We attempted to assess the therapeutic effect of exogenous interleukin-10 (IL-10) in combination with golimumab in treating heart failure (HF) in rats, and provide an experimental basis for clinical application. Methods HF animal model was induced in Sprague-Dawley (SD) rats by intraperitoneally injection with adriamycin, and rats in control group were treated with 0.9% normal saline. The HF rats were randomly divided into 4 groups: group A (HF group, n = 10), group B (IL-10 group, n = 10), group C (golimumab group, n = 10), and group D (IL-10 and golimumab group, n = 10). The normal rats were defined as controls in group E (n=10). Three months later, myocardial functional indexes and hemodynamic indexes of rats in all groups were measured. The levels of TNF-ÃŽ ± and IL-10 in serum were detected by enzyme linked immunosorbent assay (ELISA). Results The HF rat model was successfully constructed. After the treatment, compared with group A, the hemodynamic indexes in groups B-D were distinctly different (P P P P Conclusions IL-10 and golimumab has synergistic effect in the treatment of HF in rats, suggesting a potential clinical application of IL-10 combined with golimumab. Key words: cytokines; golimumab; heart failure; IL-10; TNF-ÃŽ ± INTRODUCTION Heart failure (HF) is considered to be a condition in which the heart can hardly pump sufficient blood to meet the need of the body [1]. It was demonstrated that HF is closely related to several diseases such as hypertension, ischemic heart disease, diabetes, obesity and dyslipidaemia [2]. HF has already been a major cause of morbidity and mortality worldwide [3, 4]. It was reported that more than23 million people in the world are suffering from HF [1]. Mortality caused by HF is up to 30%-40% within one year, and rise to a rate of 50%-75% within 5 years [5, 6]. So, HF has been a health concern all over the world. Previous studies suggested that the imbalance of anti-inflammatory and pro-inflammatory cytokines played a key role in the progression of HF [7]. Recent studies have highlighted the effects of some cytokines on immune-mediated myocyte injury, postischemic myocardial inflammation, and heart function. Levels of anti-inflammatory cytokines such as interleukin-10 (IL-10) are reduced in HF development [8-11]. Evidences demonstrated IL-10 controlled inflammation by inhibiting pro-inflammatory cytokine synthesis and inducted antiapoptotic processes [12]. IL-10 can promote healing of ventricular damage to avoid ventricular remodeling [13, 14]. IL-10 can enhance humoral immunity by inhibiting cell-mediated immunity to resist HF. Thus, IL-10 is considered to be a candidate for the management of HF, [12]. Serum level of pro-inflammatory cytokines of tumor necrosis factor ÃŽ ± (TNF-ÃŽ ±) are found to be elevated in experimental models of HF [15]. Studies declared that an increase of TNF-ÃŽ ± con centration resulted in necrosis and apoptosis of myocardial cells, finally led to ventricular remodeling by the progressive thinning and expansion of ventricular wall [16]. TNF-ÃŽ ± was reported to lower the myocardial systolic function directly [13, 14]. Furthermore, evidences uncovered the relationship of TNF-ÃŽ ± and progression of HF: elevated level of TNF-ÃŽ ± contributed to the development and progression of HF by activation of matrix metalloproteinases, and promotion of myocardial hypertrophy and contractile dysfunction [12]. Therefore, the TNF-ÃŽ ± inhibitors, as medicines for HF treatment, had been becoming the current hot topics in HF studies. Nowadays, etanercept, a recombinational TNF-ÃŽ ± inhibitor, had been synthesized already, which inhibit the pro-inflammatory of TNF-ÃŽ ± due to the interdicted effect for the conjugation of TNF-ÃŽ ± and cell membrane receptor [17]. Golimumab, another TNF-ÃŽ ± inhibitor, is a monoclonal antibody specific for human TNF-ÃŽ ± [18]. It can inhibit the bioactivity of TNF-ÃŽ ± via binding to TNF-ÃŽ ± with high affinity and specificity to prevent TNF-ÃŽ ± from combination with TNF receptor [19]. In addition, IL-10 has been shown to play a pivotal role in the mucosal immune system by inhibition of pro-inflammatory cytokine synthesis such as TNF-ÃŽ ± [20, 21]. However, there are few studies reporting the effect of exogenous IL-10 combined with golimumab forthe HF treatment. In the present study, we used HF rats model, which was induced by intraperitoneal injection with adriamycin (ADR), to explore the effect of exogenous IL-10 combined with golimumab in the treatment for HF. To analyze the therapeutic effects, IL-10 or/and golimumab were intraperitoneally injected into the HF rats and the effects of the treatments were tested by measuring heart functional indexes and level of inflammatory cytokines. In addition, the possible mechanisms of this effect were investigated. MATERIALS AND METHODS Rats model of heart failure Fifty 10-week-old Sprague-Dawley (SD) rats, including 25 females and 25 males, were provided by Laboratory animal center, southern medical university Southern Medical University. Forty rats, with 20 females and 20 males, were chosen at random. Rats with HF were induced by intraperitoneal injection with 4 mg/kg adriamycin (ADR) once a week for 6 times. Control rats were given the same volume of normal saline. Experimental design and drug administration After 6 weeks, the model rats were randomly divided into 4 experimental groups: HF group (group A, n=10), IL-10 group (group B, n=10), golimumab group (group C, n=10), and IL-10 and golimumab group (group D, n=10), with 5 females and 5 males in each group. The normal rats were considered as controls in group E (n=10). Rats in group B was given an intraperitoneally injection of 50 pg/kg IL-10 each week. Exactly, 1 mg/kg golimumab (Centocor Ortho Biotech Inc) was administered intraperitoneally into the rats in group C each month. Rats in group D was intraperitoneally injected with 50 pg/kg IL-10 each week and 1 mg/kg golimumab each month. At the same time, rats in groups A and E received an intraperitoneal injection of 1ml normal saline. Rats in each group were treated for 3 times in total. During the test period, rats were fed on food and clean water freely. Echocardiography Three months after administration, echocardiographic indicators were obtained using a color doppler ultrasonic cardiograph (Vingmed CFM-725). Rats were anaesthetized with 5 ml/kg urethane solution at a concentration of 20% by intraperitoneal injection, and left ventricular long-axis and M-mode curve at the level of the left papillary muscles were measured. Finally, the left ventricle end-diastolic diameter (LVEDD), the left ventricle end-systolic diameter (LVESD), left ventricular posterior wall depth (LVPWD) were measured, and the left ventricle fractional shortening (LVFS) can be calculated by the factors above, the formula is as follows: à £Ã¢â€š ¬Ã¢â€š ¬LVFS = [( LVEDDà ¯Ã‚ ¼Ã‚ LVESD)/LVEDD]Ãâ€"100%. Measurements of haemodynamic parameters After anaesthetization, rats were fixed followed bytracheal intubationwith artificial ventilation. Super-miniature cardiac catheter was connected to multipurposepolygraph (Nikon 4) through the right common carotid artery and ascending aorta. Systolic pressure (ASP), diastolic pressure (ADP) and heart rate (HR) was recorded. As a follow-up, the cardiac catheter were inserted into the left ventricle, the left ventricle systolic pressure (LVSP), the left ventricular end-diastolic pressure (LVEDP) and the maximum rate of the left ventricular pressure rise (+dp/dtmax) and decline (-dp/dtmax) were measured. Then, allratsweresacrificed to weight the body. Their hearts were weighted after washing by cold normal saline and drying by filter paper. Finally, Heart weight/Body weight (HW/BW, mg/g) was calculated based on HW and BW. Determination of the level of TNF-ÃŽ ± and IL-10 in serum After hemodynamic evaluation, 2 ml blood samples were drawn from the catheter positioned in the left common carotid artery, and collected into a 2 ml tube. After 30 min, the blood samples were centrifuged at 3000 r/min for 10 min. The supernatant were collected into Eppendorf (EP) tube. The concentration of TNF-ÃŽ ± and IL-10 in serum were detected by using an ELISA kit (RayBiotech. Inc), and experimental procedures were conducted according to themanufacturer’sinstructions stringently. Statistical analysis The data were represented as mean  ± standard deviation (SD). Comparisons between groups were analyzed by one-way ANOVA and q-test (Student-Newman-Kueulsmethod). All statistical analyses were performed by using SPSS 12.0 software (SPSS, Chicago, IL). P RESULTS Heart function When the model establishment was completed, all of the rats suffered from HF, showing symptoms including dyspnea, edema, feed difficulty and oliguria. HF symptoms of the rats in groups B-D were alleviated after the treatment with IL-10, golimumab, and IL-10 and golimumab respectively. Obviously, symptoms of the rats in group D were most significantly alleviated. There was no rat died during the experimentation. Changes of BW, HW and HW/BW in the rats after treatment As shown in table 1, the BW and HW of the rats in groups A-D decreased significantly in contrast to those in group E (P P significantly when compared with group A (P > 0.05). The BW and HW of the rats in group D were markedly increased compared with group A (422.85 ±34.45 mg vs. 315.45 ±20.56 mg; 1355.29 ±112.23 mg vs. 1154.58 ±135.48 mg, P P The results of echocardiography Table 2 presents the results of echocardiography in the rats. Compared with E group, LVEDD and LVESD of the rats in groups A-D increased significantly (P P P (50.47 ±6.48 %) in group D was higher than group A (30.37 ±4.35 %, P P > 0.05). The hemodynamic indexes changes Hemodynamic parameters of the rats in group A had a difference in statistical significance when compared with group E (table 3). After treated with IL-10 and golimumab, ASP and ADP in group D was significantly increased when compared with group A (155.89 ±23.45 mmHg vs. 108.35 ±35.58 mmHg; 114.26 ±13.65 mmHg vs. 114.26 ±13.65 mmHg, P most markedly increased compared with group A (125.58 ±28.87 mmHg vs. 85.25 ±15.34 mmHg, P groups B and C. LVEDP in group D (5.23 ±0.68 mmHg) was most significantly decreased contrasted with group A (12.45 ±1.21 mmHg, P P Level of serum TNF-ÃŽ ± and IL-10 Compared with group E, the level of serum TNF-ÃŽ ± in groups A-D rose obviously (P P most significantly increased in group D when compared with group A (643.66 ±78.43 pg/ml vs 275.58 ±56.62 pg/ml, P DISCUSSION Heart failure (HF), as a complex clinical syndrome, is the ultimate end-result of various cardiovascular diseases and the main cause of death [7]. HF prevention and treatment have drawn more and more attention inthemedicalfield. It has been reported that TNF-ÃŽ ± played a central role in the progression of HF [12]. Studies indicated that golimumab, as a monoclonal antibody, had effective on inflammation based on inhibition on pro-inflammatory cytokine of TNF-ÃŽ ± [18, 19], moreover, the effect of TNF-ÃŽ ± in many tissue es is modulated by IL-10 [22]. In the present study, we used HF rats model to determine the effect of exogenous IL-10 combined with golimumab in the treatment for HF. The therapeutic effect of IL-10 combined with golimumab for HF in rats was evaluated according to heart function (changes of heart weight, echocardiographic and hemodynamic indicators) and the variation in the level of serum IL-10 and TNF-ÃŽ ±. To the best our knowledge, heart hypertrophy ultimately leads to HF [23], and the increase of HW/BW represents a tendency of heart hypertrophy [7]. In the present study, no obvious changes of HW/BW were observed in groups B (IL-10 group) and C (golimumab group) compared with group A (HF group). But HW/BW in group D (IL-10 and golimumab group) was markedly decreased obviously when compared with group A (HF group). These results indicate that treatment with either IL-10 or golimumab is less effective than the combination of IL-10 and golimumab for relieving heart hypertrophy. Studies indicated that treatment targeted the pathological disease such as heart hypertrophy was effective for HF [24].Therefore, our results suggest IL-10 combined with golimumab may have significant effects on prevention of HF. In addition, previous studies suggested that elevated LVEDD and LVESD and declined LVFS led to ventricular remodeling and culminated in progressive HF [25]. Based on the echocardiographic data in the present study, we found that LVEDD and LVESD decreased markedly, and LVFS increased in groups B-D compared with group A. Particularly, the most remarkable variation was observed in group D. these results suggest that IL-10 combined with golimumab are more effective inthe treatment of HF by relieving ventricular remodeling. Moreover, changes of hemodynamic parameters are regarded as an important signal of myocardial function which results in HF development [26]. In the present study, the hemodynamic measurements were improved in group D compared with groups A by increasing ASP, ADP, LVSP, LVEDP, and  ±dp/dtmax and decreasing LVEDP. Our observations were consistent with the previous findings showing that LVSP, LVEDP, and  ±dp/dtmax were increaded and LVEDP was decreased after completing the study of the HF rats. Furthermore, the previous studies declared that the deterioration of myocardial function in HF rats was more significantly alleviated based on the improvement of hemodynamic measurements after treatment [26, 27]. Notably, in our study, hemodynamic parameters in group D were improved compared with groups B and C. Therefore, the results of this study suggest that IL-10 and golimumab may have synergistic effects on improvement of myocardial function to relieve HF symptoms. Furthermore, in the present study, the level of IL-10 and TNF-ÃŽ ± were detected. The level of serum IL-10 was elevated in groups B-D compared to group A. Similarly, studies observed that an increase in IL-10 content was showed after effective treatment and suggested that improvement in cardiac function was connected with the elevated level of IL-10 [28-30]. Moreover, level of serum IL-10 in group D was higher than groups B and C, this suggest that the combination of IL-10 and golimumab can most significantly induce the elevation in the level of serum IL-10. Meantime, the results of our study showed that the level of serum TNF-ÃŽ ± in the rats of HF was significantly declined in group D compared with group A, while we noted that the treatment with IL-10 or golimumab only affected little the concentration of serum TNF-ÃŽ ± in groups B and C. This led us to hypothesize that golimumab is less effective in inhibition of the expression of TNF-ÃŽ ±, but more effective when combined with IL -10. As previous studies declared, TNF-ÃŽ ± plays a central role in initiating and sustaining the inflammatory response [31] and is a mediator of cardiac pathology acting through inflammatory pathways and activation of myocardial apoptosis [32, 33]. On the other hand, IL-10 inhibits cytokine-induced oxidative stress along with affecting the expression of inflammatory cytokines [34]. It is suggested that the imbalance between the IL-10 and TNF-ÃŽ ± in the heart may result in an inflammatory response, which plays a pathogenic role in the development and progression of HF [12]. The changes of the serum level of IL-10 and TNF-ÃŽ ± in our study suggest that IL-10 and golimumab may modulate the inflammatory processes by promoting the expressing of IL-10 and suppressing the expression of TNF-ÃŽ ±. Therefore, The combination of IL-10 and golimumab may be more effective than IL-10 or golimumab in the treatment of HF via inflammatory pathways. In conclusion, exogenous IL-10 and golimumab had synergistic effects on HF in rats based on the improvement in myocardial function and prevention of heart hypertrophy and ventricular remodeling through inflammatory pathways. Furthermore, the synergistic effect of IL-10 and golimumab is superior to the effect of treatment with IL-10 or golimumab only. Our results suggest that the combination of IL-10 with golimumab may be a promising treatment for HF patients. Further study is warranted to verify the efficiency of IL-10 combined with golimumab in human clinical trials.